The Role of Leukemia Inhibitory Factor in Counteracting the Immunopathology of Acute and Chronic Lung Inflammatory Diseases

Leukemia inhibitory factor (LIF), a member of the IL-6 cytokine family, is highly expressed throughout body in multiple tissues and cell types. LIF primarily known to induce differentiation myeloid leukemia cells, but recent studies show that has many other functions, including playing roles cancer normal physiology. expression linked cellular proliferation, metastasis, inflammation, chemoresistance. secretion are triggered by means its downstream signaling can vary based on tissue Recent publications suggest may play role pulmonary diseases regulation altered through external factors, such as cigarette smoke, inflammation stimuli, or infections. This review outlines current knowledge function protein, mediators expression, receptors it interacts with, signaling, possible outcomes mediated LIF.